The Metabolism and Growth of Web Forums

We view web forums as virtual living organisms feeding on user's attention and investigate how these organisms grow at the expense of collective attention. We find that the "body mass" ($PV$) and "energy consumption" ($UV$) of the studied forums exhibits the allometric growth property, i.e., $PV_t \sim UV_t ^ \theta$. This implies that within a forum, the network transporting attention flow between threads has a structure invariant of time, despite of the continuously changing of the nodes (threads) and edges (clickstreams). The observed time-invariant topology allows us to explain the dynamics of networks by the behavior of threads. In particular, we describe the clickstream dissipation on threads using the function $D_i \sim T_i ^ \gamma$, in which $T_i$ is the clickstreams to node $i$ and $D_i$ is the clickstream dissipated from $i$. It turns out that $\gamma$, an indicator for dissipation efficiency, is negatively correlated with $\theta$ and $1/\gamma$ sets the lower boundary for $\theta$. Our findings have practical consequences. For example, $\theta$ can be used as a measure of the "stickiness" of forums, because it quantifies the stable ability of forums to convert $UV$ into $PV$, i.e., to remain users "lock-in" the forum. Meanwhile, the correlation between $\gamma$ and $\theta$ provides a convenient method to evaluate the `stickiness" of forums. Finally, we discuss an optimized "body mass" of forums at around $10^5$ that minimizes $\gamma$ and maximizes $\theta$.Comment: 6 figure

Microbial diversity and biogenic methane potential of a thermogenic-gas coal mine

The microbial communities and biogenic methane potential of a gas coal mine were investigated by cultivation-independent and cultivation-dependent approaches. Stable carbon isotopic analysis indicated that in situ methane in the coal mine was dominantly of a thermogenic origin. However, a high level of diversity of bacteria and methanogens that were present in the coal mine was revealed by 454 pyrosequencing, and included various fermentative bacteria in the phyla of Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria, and acetotrophic, hydrogenotrophic, and methylotrophic methanogens. Methane was produced in enrichments of mine water samples supplemented with acetate under laboratory conditions. The microbial flora obtained from the enrichments could stimulate methane formation from coal samples. 16S rRNA gene clone library analysis indicated that the microbial community from coal cultivation samples supplemented with the enriched microbial consortium was dominated by the anaerobic fermentative Clostridiales and facultative acetoclastic Methanosarcina. This study suggests that the biogenic methane potential in the thermogenic-gas coal mine could be stimulated by the indigenous microorganisms

Collective cell migration: Implications for wound healing and cancer invasion.

During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration. During such migration, cells move as coherent groups, large cell sheets, strands or tubes rather than individually. One unexpected finding regarding collective cell migration is that being a "multicellular structure" enables cells to better respond to chemical and physical cues, when compared with isolated cells. This is important because epithelial cells heal wounds via the migration of large sheets of cells with tight intercellular connections. Recent studies have gained some mechanistic insights that will benefit the clinical understanding of wound healing in general. In this review, we will briefly introduce the role of collective cell migration in wound healing, regeneration and cancer invasion and discuss its underlying mechanisms as well as implications for wound healing